Purification of biological conjugates by size exclusion chromatography

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United States of America Patent

PATENT NO 10023607
APP PUB NO 20140066605A1
SERIAL NO

13773192

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Abstract

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A method for separating a biological conjugate from an aggregate. The molecular weight of the biological conjugate ranges from about 10 kDa to about 1000 kDa. In one embodiment, the method comprises the steps of:

    (e) providing a mixture comprising the biological conjugate and the aggregate, wherein the biological conjugate has a molecular weight of from about 10 kDa to about 1000 kDa;(f) providing a chromatography column containing a gel, wherein the gel comprises at least one polysaccharide;(g) introducing the mixture of step (a) into the chromatography column;(h) recovering the biological conjugate from the column.

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Patent Owner(s)

  • ABBOTT LABORATORIES

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
De, Leon Gatti Marcela Arlington Heights, US 2 0
Huang, Yingqing Mundelein, US 5 19
Schisla, David K Pleasant Prairie, US 7 109
Sheu, Lou-Hwa J Gurnee, US 2 0
Tomas, Christopher A Wauconda, US 3 30

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