Polyhydroxylated pentacyclic triterpene acids as HMG-COA reductase inhibitors

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United States of America Patent

PATENT NO 10047034
APP PUB NO 20150133552A1
SERIAL NO

14401699

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Abstract

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The present invention relates to certain polyhydroxylated pentacyclic triterpene acids of formula (I) for use as HMG-CoA reductase inhibitors in the prophylactic and/or therapeutic treatment of a disease, disorder or condition that responds to a reduction of the HMG-CoA reductase activity in a mammal, preferably a human being. The present invention further relates to certain mixtures and plant extracts comprising euscaphic acid and tormentic acid, wherein the amount of euscaphic acid to tormentic acid exceeds a certain ratio. Further, the present invention also relates to a formulation, preferably pharmaceutical or nutraceutical formulation, comprising one or more of said compounds of formula (I), a composition according to the present invention or a plant extract according to the present invention. Also, the present invention relates to a process for obtaining certain polyhydroxylated pentacyclic triterpene acids of formula (I), a composition according to the present invention or a plant extract according to the present invention.

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Patent Owner(s)

  • PRAIRIE BERRY EUROPE GMBH

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bitzer, Jens Dortmund, DE 10 19
Grothe, Torsten Affoltern am Albis, CH 15 42
Hans, Joachim Holzminden, DE 17 5
Köpcke, Bärbel Dortmund, DE 8 25
Küper, Thomas Reken, DE 9 50
Moldenhauer, Jana Dortmund, DE 4 14
Reinhardt, Kathrin Münster, DE 6 25
Wöhrle, Ingo Dortmund, DE 10 43

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