Negative selection and stringency modulation in continuous evolution systems

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United States of America Patent

PATENT NO 10179911
APP PUB NO 20160348096A1
SERIAL NO

15112759

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Abstract

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Strategies, systems, methods, reagents, and kits for phage-assisted continuous evolution are provided herein. These include strategies, systems, methods, reagents, and kits allowing for stringency modulation to evolve weakly active or inactive biomolecule variants, negative selection of undesired properties, and/or positive selection of desired properties.

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Patent Owner(s)

Patent OwnerAddress
PRESIDENT AND FELLOWS OF HARVARD COLLEGE17 QUINCY STREET CAMBRIDGE MA 02138

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Badran, Ahmed Hussein Somerville, US 15 364
Carlson, Jacob Charles Somerville, US 5 327
Esvelt, Kevin Michael Cambridge, US 15 513
Liu, David R Lexington, US 236 9909

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