Cell-permeable probes for identification and imaging of sialidases

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United States of America Patent

PATENT NO 10214765
APP PUB NO 20180155761A1
SERIAL NO

15881581

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Abstract

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Provided herein are compounds for use as sialidase inhibitors, including alkynyl-3-fluorosialyl fluoride. The compounds, which include the compound DFSA, function by trapping a 3-fluorosialylenzyme intermediate (reporter-inhibitor-enzyme conjugate). These compounds can be conjugated with a detectable tagging moiety for isolation and identification of sialidases.

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Patent Owner(s)

Patent OwnerAddress
ACADEMIA SINICANO 128 SEC 2 ACADEMIA RD NANKANG DIST TAIPEI 11529

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cheng, Yih-Shyun E Taipei, TW 6 109
Fang, Jim-Min Taipei, TW 33 267
Tsai, Chamg-Sheng New Taipei, TW 1 15
Wong, Chi-Huey Rancho Santa Fe, US 221 2984

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