Universal fibronectin type III bottom-side binding domain libraries

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United States of America Patent

PATENT NO 10253313
APP PUB NO 20160194626A1
SERIAL NO

14828763

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Abstract

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The invention pertains to a natural-variant combinatorial library of fibronectin Type 3 domain (Fn3) polypeptides useful in screening for the presence of one or more polypeptides having a selected binding or enzymatic activity. The library polypeptides include (a) regions A, AB, B, C, CD, D, E, EF, F, and G having wildtype amino acid sequences of a selected native fibronectin Type 3 polypeptide or polypeptides, and (b) loop regions AB, CD, and EF having selected lengths (Bottom Loops). The Fn3 may also have loop regions BC, DE, and FG having wildtype amino acid sequences, having selected lengths, or mutagenized amino acid sequences (Top Loops).

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Patent Owner(s)

Patent OwnerAddress
NOVARTIS AG4056 BASEL

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Loew, Andreas Cambridge, US 114 2037
Vash, Brian Cambridge, US 1 0

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