Methods of generating and screening for lytic chimeric polypeptides
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United States of America Patent
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May 28, 2019
Grant Date -
May 19, 2016
app pub date -
Jan 20, 2016
filing date -
Jun 18, 2010
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Abstract
The present invention relates to novel methods of generating and screening for chimeric polypeptides, which can be used in the treatment and prophylaxis of pathogenic bacterial contamination, colonization and infection. The novel methods are based on random recombination of protein domains, and the chimeric polypeptides obtainable by the methods according to the invention are characterized in that they comprise at least one enzymatic active domain (EAD) and at least one cell binding domain (CBD). The present invention also relates to a library of chimeric polypeptides obtainable by the methods of the present invention.
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