Method for designing RNA binding protein utilizing PPR motif, and use thereof

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United States of America Patent

PATENT NO 10340028
APP PUB NO 20180247018A1
SERIAL NO

15962127

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Abstract

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A method for designing a protein capable of binding in an RNA base selective manner or RNA base sequence specific manner is provided. The protein of the present invention is a protein containing one or more of PPR motifs (preferably 2 to 14 PPR motifs) each consisting of a polypeptide of 30- to 38-amino acid length represented by the formula 1 (wherein Helix A is a moiety of 12-amino acid length capable of forming an α-helix structure, and is represented by the formula 2, wherein, in the formula 2, A1 to A12 independently represent an amino acid; X does not exist, or is a moiety of 1- to 9-amino acid length; Helix B is a moiety of 11- to 13-amino acid length capable of forming an α-helix structure; and L is a moiety of 2- to 7-amino acid length represented by the formula 3, wherein, in the formula 3, the amino acids are numbered “i” (−1), “ii” (−2), and so on from the C-terminus side, provided that Liii to Lvii may not exist), and combination of three amino acids A1, A4 and Lii, or combination of two amino acids A4, and Lii is a combination corresponding to a target RNA base or base sequence.

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Patent Owner(s)

Patent OwnerAddress
KYUSHU UNIVERSITY NATIONAL UNIVERSITY CORPORATIONNISHI-KU FUKUOKA-SHI FUKUOKA 8190395

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kobayashi, Keiko Fukuoka, JP 32 131
Nakamura, Takahiro Fukuoka, JP 195 3533
Yagi, Yusuke Fukuoka, JP 27 12

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