Methods for identifying T-cell receptor antigens

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 10526598
APP PUB NO 20190345484A1
SERIAL NO

16392611

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Abstract

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The present disclosure automated methods for creating cell surface display libraries, where the cells of the library display engineered peptides on their cell surfaces for identification of antigens that bind to T-cell receptors. The engineered peptides are preferably expressed in the cells under conditions that provide both secretion and display of the engineered peptides on the cell surfaces, thus providing access of the engineered peptide antigens to identify potential TCR binding targets. The cell libraries cab be engineered using an automated editing system that provides for one or more targeted edits per cell.

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Patent Owner(s)

Patent OwnerAddress
INSCRIPTA INC5500 CENTRAL AVE SUITE 220 BOULDER CO 80301

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Church, Deanna Boulder, US 6 0
Federowicz, Stephen Boulder, US 6 0
Graige, Michael Boulder, US 15 21

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