Method for producing injectable formulations of blood-derived protein materials, and materials obtained using said method
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United States of America
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Feb 18, 2020
Grant Date -
May 1, 2014
app pub date -
Apr 8, 2011
filing date -
Apr 8, 2011
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Abstract
A method for producing injectable pharmaceutical formulations of blood-derived protein materials includes the steps of fractioning the source material in a polymer/salt aqueous two-phase system in the presence of phenol, purifying the top phase of the system by means of precipitation with caprylic acid and purifying the bottom phase by means of thermocoagulation, increasing the purity of the materials in both phases through chromatography, removing viral particles by means of the nanofiltration of both preparations, and formulating, stabilizing, and packaging the resulting materials.
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