Systems and methods of preparing stabilized lipid assemblies

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United States of America

PATENT NO 10576456
APP PUB NO 20170120218A1
SERIAL NO

15318905

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Abstract

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Direct polymerization of lipid monomers or polymer scaffolding of non-lipid monomers coupled with irradiation or redox polymerization performed at neutral pH resulted in stabilized lipid assemblies. An initiator-buffer component and NaHS03 redox mixture polymerizes reactive lipid monomers at near neutral pH conditions to preserve functionality of reconstituted membrane proteins. Improved stability of black lipid membranes (BLMs) is attained by chemical cross-linking of polymerizable, hydrophobic and commercially available non-lipid monomers partitioned into the suspended lipid membranes, and by suspending the BLMs across low surface energy apertures. Substrate apertures having low surface energy modifiers with amphiphobic properties facilitated a reproducible formation of BLMs by promoting interactions between the lipid tail and the substrate material. In addition, polymeric lipid bilayer membranes were prepared by photochemical or redox initiated polymerization of polymerizable lipid monomers, and disposed onto supporting substrates for use in chromatography columns.

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Patent Owner(s)

  • ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Aspinwall, Craig A Tucson, US 9 2
Bright, Leonard Tucson, US 1 0
Ratnayaka, Saliya N Tucson, US 1 0
Saavedra, Steven Scott Tucson, US 11 299

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