Method for manufacturing bone-regeneration material comprising biodegradable fibers by using electrospinning method

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United States of America Patent

PATENT NO 10646616
APP PUB NO 20180280569A1
SERIAL NO

15773554

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Abstract

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A bone-regeneration material that contains calcium phosphate particles in biodegradable fibers of PLGA manufactured by electrospinning. A PLGA resin is heated in a kneader until the resin viscosity becomes 102 to 107 Pa·s. A powder of calcium phosphate fine particles is added while the blade is rotated. The mixture is kneaded by continuous rotation of the blade in the heated state to disperse the calcium phosphate fine particles to obtain a composite having calcium phosphate fine particles dispersed in the PLGA resin. The composite is dissolved by a solvent, and the PLGA resin is completely dissolved by agitation for a prescribed duration to prepare a spinning solution in which the calcium phosphate fine particles are dispersed. Electrospinning is performed on the spinning solution to manufacture biodegradable fibers having therein the calcium phosphate fine particles substantially uniformly dispersed.

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Patent Owner(s)

Patent OwnerAddress
NATIONAL UNIVERSITY CORPORATION NAGOYA INSTITUTE OF TECHNOLOGYSHOWA-KU NAGOYA-SHI AICHI 466-0061
ORTHOREBIRTH CO LTD3-17-43 CHIGASAKI-HIGASHI TSUZUKI-KU YOKOHAMA-SHI KANAGAWA 224-0033

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kasuga, Toshihiro Nagoya, JP 33 382
Nishikawa, Yasutoshi Yokohama, JP 5 2

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