Silk microspheres for encapsulation and controlled release

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United States of America Patent

PATENT NO 10736943
APP PUB NO 20130243866A1
SERIAL NO

13888605

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Abstract

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A method was developed to prepare silk fibroin microspheres using lipid vesicles as templates to efficiently load therapeutic agents in active form for controlled release. The lipids are subsequently removed through the use of a dehydration agent, such as methanol or sodium chloride, resulting in β-sheet structure dominant silk microsphere structures having about 2 μm in diameter. The therapeutic agent can be entrapped in the silk microspheres and used in pharmaceutical formulations for controlled-release treatments.

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Patent Owner(s)

Patent OwnerAddress
TRUSTEES OF TUFTS COLLEGEBALLOU HALL MEDFORD MA 02155

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kaplan, David L Concord, US 273 9748
Wang, Xiaoqin Winchester, US 41 548

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