Personalized tumor biomarkers

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United States of America Patent

PATENT NO 10900088
APP PUB NO 20180230550A1
SERIAL NO

15950863

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Abstract

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Clinical management of human cancer is dependent on the accurate monitoring of residual and recurrent tumors. We have developed a method, called personalized analysis of rearranged ends (PARE), which can identify translocations in solid tumors. Analysis of four colorectal and two breast cancers revealed an average of nine rearranged sequences (range 4 to 15) per tumor. Polymerase chain reaction with primers spanning the breakpoints were able to detect mutant DNA molecules present at levels lower than 0.001% and readily identified mutated circulating DNA in patient plasma samples. This approach provides an exquisitely sensitive and broadly applicable approach for the development of personalized biomarkers to enhance the clinical management of cancer patients.

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Patent Owner(s)

Patent OwnerAddress
THE JOHNS HOPKINS UNIVERSITY3400 N CHARLES STREET BALTIMORE MD 21218

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Diaz, Luis Ellicot City, US 72 576
Kinzler, Kenneth W Baltimore, US 296 5437
Leary, Rebecca J Baltimore, US 16 294
Velculescu, Victor Dayton, US 58 758
Volgelstein, Bert Baltimore, US 3 279

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