Industrial keratinase via genetic engineering and use thereof

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United States of America Patent

PATENT NO 11041160
APP PUB NO 20200385745A1
SERIAL NO

16343630

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Abstract

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The invention relates to the technical field of industrial biotechnologies, and discloses a keratinase mutant with improved thermal stability and use thereof. The asparagine at position 181, the tyrosine at position 217, and the serine at position 236 in the keratinase derived from Brevibacillus parabrevis (CGMCC No. 10798) are engineered by site-direction mutation, and combined at random to obtain an enzyme with combined mutations. The invention realizes the remarkable improvement of the thermal stability of keratinase, and has good theoretical value and application prospect.

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Patent Owner(s)

Patent OwnerAddress
JIANGNAN UNIVERSITYNO 1800 ROAD 214122 JIANGSU LIHU BINHU DISTRICT CITY OF WUXI PROVINCE WUXI CITY JIANGSU PROVINCE 214122

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gong, Jinsong Wuxi, CN 5 0
Li, Heng Wuxi, CN 76 82
Shi, Jinsong Wuxi, CN 9 0
Su, Chang Wuxi, CN 30 45
Xu, Zhenghong Wuxi, CN 12 5

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