5′-phosphorothiolate mRNA 5′-end (cap) analogs, mRNA comprising the same, method of obtaining and uses thereof

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 11066436
APP PUB NO 20190300563A1
SERIAL NO

16073499

Stats

ATTORNEY / AGENT: (SPONSORED)

Importance

Loading Importance Indicators... loading....

Abstract

See full text

The present invention relates to nucleotides, analogs of mRNA 5′-end (cap) containing sulfur atom at the position 5′ of 7-methylguanosine nucleoside. The disclosed compounds are recognized (bound and non-hydrolyzed) by DcpS enzyme (Decapping Scavenger), and thus may find therapeutic use as inhibitors thereof. DcpS is cap-specific enzyme with pyrophosphatase activity, which was identified as a therapeutic target in the treatment of spinal muscular atrophy (SMA). Some of the compounds disclosed have additional modifications in the phosphate chain, which modulate their affinity for DcpS enzyme. The present invention also relates to mRNAs modified at the 5′ end with mRNA 5′-end (cap) analogs containing 5′-phosphorothiolate moiety, which mRNAs have an increased stability and translational activity in cellular conditions, to a method of their preparation, their uses, and to a pharmaceutical formulation containing them, wherein L1 and L2 are independently selected from the group comprising O and S, wherein at least one of L1 and L2 is not O.

Loading the Abstract Image... loading....

First Claim

See full text

Family

Loading Family data... loading....

Patent Owner(s)

Patent OwnerAddress
UNIWERSYTET WARSZAWSKI00-927 WARSZAWA

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Baranowski, Marek Warsaw, PL 12 1167
Fac-Da̧browska, Kaja Warsaw, PL 1 1
Jemielity, Jacek Warsaw, PL 8 162
Kowalska, Joanna Warsaw, PL 8 162
Nowicka, Anna Legionowo, PL 1 2
Sikorski, Paweł Warsaw, PL 1 1
Warmiński, Marcin Warsaw, PL 1 1
Wojtczak, Blażej Pabianice, PL 1 1

Cited Art Landscape

Load Citation

Patent Citation Ranking

Forward Cite Landscape

Load Citation

Maintenance Fees

Fee Large entity fee small entity fee micro entity fee due date
3.5 Year Payment $1600.00 $800.00 $400.00 Jan 20, 2025
7.5 Year Payment $3600.00 $1800.00 $900.00 Jan 20, 2029
11.5 Year Payment $7400.00 $3700.00 $1850.00 Jan 20, 2033
Fee Large entity fee small entity fee micro entity fee
Surcharge - 3.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge - 7.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge - 11.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge after expiration - Late payment is unavoidable $700.00 $350.00 $175.00
Surcharge after expiration - Late payment is unintentional $1,640.00 $820.00 $410.00