Directed evolution through mutation rate modulation
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United States of America Patent
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Jul 27, 2021
Grant Date -
Jul 5, 2018
app pub date -
Dec 20, 2017
filing date -
Dec 20, 2016
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Abstract
The present invention relates to methods and systems for the directed evolution of macromolecules. The methods involve increasing the mutation rate of an evolving organism comprising a gene of interest that encodes a gene product lacking a desired activity, whereby a mutated gene of interest is produced that encodes an evolved gene product comprising the desired activity and causing a suppression of mutagenesis. The systems comprise an evolving organism comprising a gene of interest encoding a gene product to be evolved, a host organism, and optionally, a lagoon, a cellstat and/or a suitable growth medium.
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