Inhibitors of NHE-mediated antiport

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United States of America Patent

PATENT NO 11147884
SERIAL NO

16476835

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Abstract

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The present disclosure is directed to compounds (I′) and to their use in methods for the treatment of disorders associated with fluid retention or salt overload, such as heart failure (in particular, congestive heart failure), chronic kidney disease, end-stage renal disease, liver disease, and peroxisome proliferator-activated receptor (PPAR) gamma agonist-induced fluid retention. The present disclosure is also directed to compounds (I′) and their use in methods for the treatment of hypertension. The present disclosure is also directed to compounds (I′) and to their use in methods for the treatment of gastrointestinal tract disorders, including the treatment or reduction of pain associated with gastrointestinal tract disorders.

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Patent Owner(s)

Patent OwnerAddress
ARDELYX INC34175 ARDENWOOD BLVD FREMONT CA 94555

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dotsenko, Irina Fremont, US 11 14
Dragoli, Dean Fremont, US 19 31
Lewis, Jason Fremont, US 76 920

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