Catalytic signal enhancement for lateral flow immunoassays

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 11209429
APP PUB NO 20190391138A1
SERIAL NO

16401411

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Abstract

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The present invention provides a method for increasing the sensitivity of LFIAs by using palladium nanoparticles, selecting appropriate dye chemistries, and improving the timing of the development chemistry. In the presence of a palladium nanoparticle, three reagents interact with a catalytic label to form a colored dye. The three reagents include a hydrogen peroxide source, a color developer (a substituted para-phenylenediamine), and a color coupler (e.g. a napthol or a phenol). The timing of the development chemistry is improved by any combination of using a reducing agent, delaying hydrogen peroxide application by diffusion, using dissolving materials as a time delay, using serpentine flow, and separating the color coupler and the color developer on the strip.

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Patent Owner(s)

Patent OwnerAddress
THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVYONE LIBERTY CTR 875 NORTH RANDOLPH ST SUITE 1425 CHIEF OF NAVAL RESEARCH OFFICE OF COUNSEL (ATTN CODE OOCCIP) ARLINGTON VA 22203

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kidwell, David A Alexandria, US 33 645

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