Multivalent glycan microarray platform

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 11231415
APP PUB NO 20190128881A1
SERIAL NO

16099604

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Abstract

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The present invention includes a multivalent glycan microarray for detection of glycan-binding proteins. The multivalent glycan microarray allows a multivalent presentation of glycan on a microarray substrate, which can enhance binding of the glycan binding protein to the glycan microarray. The multivalent microarray includes a solid substrate having one or more branched polymers bonded to it via one or more silane-based linker reagents. The branched polymer in turn is bonded to a glycan, via one or more bifunctional linkers to form the multivalent glycan microarray. Nonspecific binding of glycan binding proteins to the multivalent glycan microarray can be reduced by using a blocking reagent coated on to the microarray substrate, which includes a polyethylene glycol surfactant attached to the solid substrate via a self-crosslinking azido-functionalized silane. Methods for making multivalent glycan microarrays and methods for using same to detect glycan-binding proteins are also disclosed.

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Patent Owner(s)

Patent OwnerAddress
Z BIOTECH LLC12635 E MONTVIEW BOULEVARD SUITE 214 FITZSIMONS BIOSCIENCE PARK CENTER AURORA CO 80045

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Zhang, Jian Aurora, US 1504 17611

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