Method for in situ determination of nucleic acid proximity

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 11279974
APP PUB NO 20170362649A1
SERIAL NO

15532353

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Abstract

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Disclosed is an in situ method for detecting spatial proximity relationships between nucleic acid sequences, such as DNA, in a cell. The method includes: providing a sample of one or more cells comprising nucleic acids; fragmenting the nucleic acids present in the cells that leaves 5′ overhanging ends; filling in the overhanging ends with at least one labeled nucleotide; joining the filled in end of the fragmented nucleic acids that are in close physical proximity to create one or more end joined nucleic acid fragments having a junction; isolating the one or more end joined nucleic acid fragments using the labeled nucleotide; and determining the sequence at the junction of the one or more end joined nucleic acid fragments.

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Patent Owner(s)

Patent OwnerAddress
BAYLOR COLLEGE OF MEDICINEONE BAYLOR PLAZA HOUSTON TX 77030

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dudchenko, Olga Houston, US 6 62
Lander, Eric Cambridge, US 15 166
Lieberman-Aiden, Erez Houston, US 1 59
Rao, Suhas Medfield, US 8 109
Stamenova, Elena Reading, US 9 64

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