Methods for the preparation of ribosides

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United States of America Patent

PATENT NO 11344565
APP PUB NO 20160122356A1
SERIAL NO

14926063

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Provided are methods of preparing compounds and pharmaceutical compositions comprising a compound Formula VIII for treating Filoviridae virus infections. In one aspect, the compound of Formula VIII is formed from a reaction mixture comprising the compound of Formula IX, the compound of Formula X, a coupling agent such as magnesium chloride and a non-nucleophilic base such as diisopropylethylamine. The compound of Formula IX can be formed from a compound of Formula V and a cyanating agent. The compound of Formula V can be synthesized from a reaction mixture comprising a deprotonating agent such as phenylmagnesium chloride; a silylating agent such as chlorotrimethylsilane; a coupling agent such as isopropylmagnesium chloride, an additive such as LaCl3-2LiCl, LaCl3, CeCl3, NdCl3, or YCl3; a compound of Formula VI; and 7-iodopyrrolo[2,1-f][1,2,4]triazin-4-amine. The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.

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Patent Owner(s)

  • GILEAD SCIENCES, INC.

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Axt, Steven Donald Redwood City, US 3 75
Badalov, Pavel Robertovich Edmonton, CA 3 75
Brak, Katrien Belmont, US 9 141
Campagna, Silvio Edmonton, CA 17 133
Chtchemelinine, Andrei San Mateo, US 5 77
Doerffler, Edward Foster City, US 30 729
Frick, Morin Mae San Mateo, US 9 84
Gao, Detian Edmonton, CA 6 108
Heumann, Lars V Redwood City, US 24 251
Hoang, Brittanie San Francisco, US 3 75
Lew, Willard San Mateo, US 33 492
Milburn, Robert Ronald Belmont, US 5 75
Neville, Sean Timothy San Mateo, US 3 75
Ross, Bruce El Granada, US 28 811
Rueden, Erik San Mateo, US 4 75
Scott, Robert William San Mateo, US 24 184
Siegel, Dustin San Carlos, US 51 796
Stevens, Andrew C Edmonton, CA 10 115
Tadeus, Clarissa San Carlos, US 3 75
Vieira, Tiago Edmonton, CA 13 134
Waltman, Andrew W San Francisco, US 11 226
Wang, Xianghong Dublin, US 49 725
Whitcomb, Mark Charles Woodside, US 4 75
Wolfe, Lydia San Mateo, US 3 75
Yu, Chia-Yun Edmonton, CA 5 75

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