Organolithium process under continuous flow conditions

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United States of America Patent

PATENT NO 11407769
APP PUB NO 20210040124A1
SERIAL NO

16763775

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Abstract

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The invention relates to methods for CC bond formation using organolithium compounds under continuous flow conditions in a micro or mesoreactor system, wherein an organic substrate is reacted with an alkyl lithium compound in the presence of a donor solvent to form a Li intermediate, which can be reacted in situ or subsequently in a second reaction step with an electrophile to form an organic secondary product, the organolithium compound RLi being used as a solution in a hydrocarbon or hydrocarbon mixture and the RLi concentration being at least 3 M, preferably at least 4 M.

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Patent Owner(s)

Patent OwnerAddress
ALBEMARLE GERMANY GMBH65926 FRANKFURT AM MAIN

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Nikbin, Nikzad Cambridge, GB 2 0
Schnippering, Stefan Siegburg, DE 2 0
Tarver, Gary John Stevenage, GB 1 0
Wietelmann, Ulrich Friedrichsdorf, DE 92 312

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