Lossless cryo-grid preparation stage for high-resolution electron microscopy

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United States of America Patent

PATENT NO 11422074
APP PUB NO 20180209881A1
SERIAL NO

15742532

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Abstract

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The invention relates to a preparation system and method for preparing a sample for electron microscopy, the preparation system comprising: a liquid handling system (0) comprising a dispensing head (1), wherein said liquid handling system (0) is configured to aspirate and dispense a volume of a sample via the dispensing head (1), a support structure (2) that is configured to accommodate the sample, a temperature-controlled stage (4) that is configured to keep said support structure (2) at a pre-defined temperature, a first adapter (3) configured to hold said support structure (2), and a transfer mechanism (60) that is configured to be connected to the first adapter (3) holding the support structure (2) and to move said support structure (2) into a container (8) containing a liquid cryogen (80) so that the sample on the support structure (2) contacts the cryogen (80).

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITAT BASEL4001 BASEL

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Arnold, Stefan Alexander Basel, CH 1 1
Braun, Thomas Munchenstein, CH 64 398
Stahlberg, Henning Binningen, CH 2 2

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