Isobaric mass labels having n',n'-dimeihyl piperazine-2-carboxylic acid reporter moieties

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United States of America Patent

PATENT NO 11453621
APP PUB NO 20180362416A1
SERIAL NO

16061136

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Abstract

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The present invention relates to a set of two or more mass labels, wherein each mass label comprises the formula:

description='In-line Formulae' end='lead'X-L-M-Redescription='In-line Formulae' end='tail'

wherein X is a reporter moiety having an exact mass, L is a bond cleavable by collision in a mass spectrometer, M is a mass modifier, and Re is a) a reactive functionality for attaching the mass label to an analyte or b) the analyte, wherein each mass label in the set has an integer mass, wherein each mass label in the set has the same integer mass, and wherein the set comprises two or more subsets of mass labels, each subset comprising one, two or more mass labels, and wherein, when the subset comprises two or more mass labels, the exact mass of the reporter moiety X of each mass label in the subset is different from the exact mass of the reporter moiety X of the mass labels in the same subset and in all other subsets, and wherein each mass label is distinguishable by mass spectrometry.

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Patent Owner(s)

Patent OwnerAddress
ELECTROPHORETICS LIMITEDCOBHAM SURREY KT11 3EP

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Thompson, Andrew Hugin Cambridge, GB 28 584

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