Heavy metal ion-hematein-complexes useful as ex vivo contrast agent for a computed tomography scanning of a biological sample, ex vivo method for investigating a biological sample, and use of the complexes

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United States of America Patent

PATENT NO 11561155
APP PUB NO 20200271554A1
SERIAL NO

16755661

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Abstract

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The present invention relates to specific complexes comprising heavy metal ions having an atomic number of 23 or higher and 83 or lower (in particular Ag1+, Ba2+, Pb2+, Gd3+ and Bi3+) and one or more hematein ligand(s). In particular, the invention relates to the use of the complexes as ex vivo contrast agents for a computed tomography scanning of a biological sample. Moreover, the invention relates to specific ex vivo methods for investigating a biological sample by means of computed tomography scanning methods, wherein the method comprises staining the biological sample with a solution comprising one or more of the complex(es); or wherein the method comprises staining the biological sample with a staining solution comprising hematein, and separately contacting the biological sample with one or more staining solution(s) comprising one or more heavy metal ions having an atomic number of 23 or higher and 83 or lower (in particular Ag1+, Ba2+, Pb2+, Gd3+ and Bi3+).

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Patent Owner(s)

Patent OwnerAddress
TECHNISCHE UNIVERSITAT MUNCHENARCISSTRASSE 21 MÜNCHEN 80333

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Busse, Madleen Eching, DE 3 18
Pfeiffer, Franz Unterföhring, DE 31 1193

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