Non-replicative transduction particles with one or more non-native tail fibers and transduction particle-based reporter systems

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United States of America Patent

PATENT NO 11572595
APP PUB NO 20200208226A1
SERIAL NO

16722724

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Abstract

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The present invention relates to compositions comprising and methods of producing genetically engineered bacteriophages, bacteriophage-like particles and non-replicating transduction particles (NRTPs) that contain non-native tail fibers that display altered host specificity and/or reactivity. The present invention also relates to methods of using these bacteriophages and NRTPs for the development of novel diagnostics, therapeutics and/or research reagents for bacteria-related diseases.

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Patent Owner(s)

Patent OwnerAddress
ROCHE MOLECULAR SYSTEMS INCPLEASANTON CA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Alexander, Jeffrey Hayward, US 13 126
Cady, Kyle C Santa Clara, US 10 24
Chu, Kristina Pleasanton, US 2 0
Eckert, Barbara El Cerrito, US 10 14
Goldman, Dylan San Jose, US 2 0
Lam, Colin Redwood City, US 2 0
Lin, Patrick San Jose, US 47 636
Mangipudi, Kalyani Pleasanton, US 12 3
Mehta, Misha Pleasanton, US 2 0
Moghaddasi, Arrash Sunnyvale, US 4 0
Nguyen, Hai San Jose, US 44 278
Sorenson, Natacha Los Gatos, US 3 0

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