Method for preparation of derivatives of gram-positive bacteria surface capsular polysaccharide

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United States of America Patent

PATENT NO 11603416
APP PUB NO 20210002388A1
SERIAL NO

17004067

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Abstract

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The present disclosure discloses a method for preparation of derivatives of gram-positive bacteria surface capsular polysaccharide, and belongs to the field of carbohydrate chemistry. The present disclosure takes glucose as a glycosyl donor to obtain a target β-glucosidic bond, then successfully synthesizes a disaccharide building block through a method of redox of a glucose C-2 site, and then takes the disaccharide building block as a repeat unit to synthesize a target oligosaccharide structure such as a derivative [→3)-α-D-Manp-(1→4)-β-D-Rhap-(1→]5-Linker of gram-positive bacteria cell wall capsular polysaccharide. A reduction end of decose is linked with a linker to be linked with a protein to make glycoconjugates for immunological studies. The method provided by the present disclosure is simple, time-saving, labor-saving and low-cost, and the resultant derivatives of the gram-positive bacteria surface capsular polysaccharide may be used for development and preparation of medicine related to autism.

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Patent Owner(s)

Patent OwnerAddress
JIANGNAN UNIVERSITYWUXI JIANGSU 214122

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cai, Juntao Wuxi, CN 1 0
Hu, Jing Wuxi, CN 117 583
Yin, Jian Wuxi, CN 109 2509

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