Pyridinium salts as activators in the synthesis of stereodefined oligonucleotides

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United States of America Patent

PATENT NO 11667660
APP PUB NO 20210355150A1
SERIAL NO

17241535

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Abstract

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The present invention relates to a method for preparing stereodefined phosphorothioate oligonucleotides, especially locked stereodefined phosphorothioate oligonucleotides with a high yield, using pyridinium acidic salts as a coupling activator.

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ROCHE INNOVATION CENTER COPENHAGEN A/S2970 HØRSHOLM

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Funder, Erik Daa Hilleroed, DK 7 8
Hansen, Dennis Jul Farum, DK 13 14

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