Lipids and compositions for the delivery of therapeutics

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United States of America Patent

PATENT NO 11712476
SERIAL NO

17357122

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Abstract

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The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention formula (I) provides lipids having the following structure XXXIII wherein: R1 and R2 are each independently for each occurrence optionally substituted C10-C30 alkyl, optionally substituted C10-C30 alkenyl, optionally substituted C10-C30 alkynyl, optionally substituted C10-C30 acyl, or -linker-ligand; R3 is H, optionally substituted C1-C10 alkyl, optionally substituted C2-C10 alkenyl, optionally substituted C2-C10 alkynyl, alkylhetrocycle, alkylphosphate, alkylphosphorothioate, alkylphosphorodithioate, alkylphosphonates, alkylamines, hydroxyalkyls, ω-aminoalkyls, ω-(substituted)aminoalkyls, ω-phosphoalkyls, ω-thiophosphoalkyls, optionally substituted polyethylene glycol (PEG, mw 100-40K), optionally substituted mPEG (mw 120-40K), heteroaryl, heterocycle, or linker-ligand; and E is C(O)O or OC(O).

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Patent Owner(s)

Patent OwnerAddress
ARBUTUS BIOPHARMA CORPORATION100-8900 GLENLYON PARKWAY BURNABY BRITISH COLUMBIA V5J 5J8

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ansell, Steven Cambridge, US 10 877
Chen, Jianxin Cambridge, US 60 1393
Eltepu, Laxman Cambridge, US 33 758
Jayaraman, Muthusamy Cambridge, US 107 3970
Mancharan, Muthiah Cambridge, US 1 0
Rajeev, Kallanthottathil G Cambridge, US 260 8660

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