Self-assembling protein nanostructures displaying paramyxovirus and/or pneumovirus F proteins and their use

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United States of America Patent

PATENT NO 11732011
SERIAL NO

17523174

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Abstract

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Disclosed herein are nanostructures and their use, where the nanostructures include (a) a plurality of first assemblies, each first assembly comprising a plurality of identical first polypeptides; (b) a plurality of second assemblies, each second assembly comprising a plurality of identical second polypeptides, wherein the second polypeptide differs from the first polypeptide; wherein the plurality of first assemblies non-covalently interact with the plurality of second assemblies to form a nanostructures; and wherein the nanostructure displays multiple copies of one or more paramyxovirus and/or pneumovirus F proteins or antigenic fragments thereof, on an exterior of the nanostructure.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITY OF WASHINGTON4545 ROOSEVELT WAY NE SUITE 400 SEATTLE WA 98105

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Baker, David Seattle, US 251 2153
Fiala, Brooke Seattle, US 6 1
King, Neil P Seattle, US 22 44
Lanzavecchia, Antonio Bellinzona, CH 80 1100
Marcandalli, Jessica Bellinzona, CH 3 0
Perez, Laurent Bellinzona, CH 5 9
Stewart, Lance Joseph Seattle, US 8 1

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