TCR libraries

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United States of America Patent

PATENT NO 11739441
SERIAL NO

17405805

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention relates to a library of particles, the library displaying a plurality of different T cell receptors (TCRs), wherein the plurality of TCRs consists essentially of TCRs comprising an alpha chain comprising an alpha chain variable domain and a beta chain comprising a beta chain variable domain and the library comprises more than one TRAV gene product and/or more than one TRBV gene product, wherein the beta chain variable domain does not comprise one or more of a TRBV5-1, 5-3, 5-4, 5-5, 5-6, 5-7 or 5-8 gene product and wherein the plurality of TCRs do not consist essentially of TCRs comprising a TRAV12-2 gene product from a natural repertoire and a TRBV6 gene product from a natural repertoire and TCRs comprising a TRAV21 gene product from a natural repertoire and a TRBV6 gene product from a natural repertoire.

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Patent Owner(s)

Patent OwnerAddress
IMMUNOCORE LIMITEDABINGDON OXFORDSHIRE OX14 4RY

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chillakuri, Chandramouli Reddy Abingdon, GB 2 2
Hood, Graham Anthony Abingdon, GB 3 2
Molloy, Peter Eamon Abingdon, GB 28 135
Sangani, Dhaval Jaykant Abingdon, GB 2 0
Volkov, Arsen Valeryevich Abingdon, GB 2 2

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