Variable epitope library compositions and methods of therapeutic and prophylactic use

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United States of America Patent

PATENT NO 11781247
SERIAL NO

16544189

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Abstract

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The present disclosure relates to compositions and methods for targeting antigenically variable pathogens and diseases. Embodiments of the present disclosure involve of the construction of variable epitope libraries (VELs) containing mutated versions of epitopes derived from antigens associated with various diseases for treating subjects in both therapeutic and prophylactic settings. The present disclosure also provides compositions and methods for the production of VELs based on CTL-derived epitopes of survivin, an oncogenic inhibitor-of-apoptosis. Given the large number of potential epitopes expressed in tumors, and the dynamic nature of the tumor epitope landscape, there is a need to develop compositions and methods for targeting various antigenic epitopes to counteract immune escape.

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Patent Owner(s)

Patent OwnerAddress
VEL PARTNERS HOLDINGS LLC36 MILL PLAIN ROAD DANBURY CT 06811-5181

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gevorgyan, Gohar Mexico City, MX 7 16
Manucharyan, Karen Mexico City, MX 11 17

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