Car-t cell assay for specificity test of novel antigen binding moieties

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United States of America Patent

PATENT NO 11788205
APP PUB NO 20200318105A1
SERIAL NO

16906931

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Abstract

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The present invention generally relates to specificity assays using cell cultures, in particular to chimeric antigen receptor (CAR) expressing reporter T (CAR-T cell) assays to test antigen binding moieties in different formats. Furthermore, the present invention relates to the use of CAR-T cells, transfected/transduced with an engineered chimeric antigen receptor (CAR) comprising a target antigen binding moiety capable of specific binding to a target antigen, e.g., tumor associated antigens.

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Patent Owner(s)

Patent OwnerAddress
HOFFMANN-LA ROCHE INCGREAT NOTCH 150 CLOVE ROAD 8TH FLOOR LITTLE FALLS NJ 07424

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Darowski, Diana Schlieren, CH 13 13
Delon, Camille Loise Sophie Schlieren, CH 4 2
Hanisch, Lydia Jasmin Schlieren, CH 16 85
Jost, Christian Schlieren, CH 8 9
Klein, Christian Schlieren, CH 571 9941
Moessner, Ekkehard Schlieren, CH 194 2920
Pulko, Vesna Schlieren, CH 4 2
Xu, Wei Schlieren, CH 934 8439

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