Process of making abaloparatide

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United States of America Patent

PATENT NO 11806387
SERIAL NO

18320544

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Abstract

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Disclosed herein is an improved process for preparing abaloparatide. The process generally utilizes solid phase peptide synthesis employing an Fmoc-protection scheme. Incorporating a systematic recoupling step of a glutamine residue (Gln16) has been found to minimize the formation of an undesirable des-Gln16 abaloparatide impurity, which is often obtained in significant quantities in the conventional process.

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Patent Owner(s)

Patent OwnerAddress
RADIUS HEALTH INC22 BOSTON WHARF ROAD 7TH FLOOR BOSTON MA 02210

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Burke, Matt Wayne, US 3 0
Campagna, Silvio Lehigh Acres, US 17 133

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