Cooling loop with a supercritical fluid system using compressed refrigerant fluid flow with a positive Joule Thomson coefficient

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United States of America

PATENT NO 11913685
SERIAL NO

17506353

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Abstract

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Provided is a chiller and system that may be utilized in a supercritical fluid chromatography method, wherein a non-polar solvent may replace a portion or all of a polar solvent for the purpose of separating or extracting desired sample molecules from a combined sample/solvent stream. The system may reduce the amount of polar solvent necessary for chromatographic separation and/or extraction of desired samples. The system may incorporate a supercritical fluid chiller, a supercritical fluid pressure-equalizing vessel and a supercritical fluid cyclonic separator. The supercritical fluid chiller allows for efficient and consistent pumping of liquid-phase gases employing off-the-shelf HPLC pumps. The pressure equalizing vessel allows the use of off-the-shelf HPLC column cartridges. The system may further incorporate the use of one or more disposable cartridges containing silica gel or other suitable medium. The system may also utilize an open loop cooling circuit using fluids with a positive Joule-Thomson coefficient.

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Patent Owner(s)

Patent OwnerAddress
SUPERCRITICAL FLUID TECHNOLOGIES INC1 INNOVATION WAY SUITE 303 NEWARK DE 19711

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ebersold, Curtis Newark, US 7 17
Ferrara, Kim Middletown, US 11 34
James, Kenneth Joseph Newark, US 10 37
Krewson, Kenneth Richard Allentown, US 10 37
Waibel, Brian Jeffrey Kennett Square, US 10 54

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