HNQO1-activatable fluorescent probe for imaging cancer cells in-vitro and in-vivo

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United States of America Patent

PATENT NO 11957766
APP PUB NO 20210154330A1
SERIAL NO

16950107

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Abstract

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The present invention includes a probe, an assay, a method of detecting, a human NAD(P)H quinone oxidoreductase-1 (hNQO1) enzyme activity with a fluorescent probe comprising a quinone propionic acid (QPA) conjugated to dicyanoisophorone (DCP), wherein the hNQO1 reduces the probe to releases a fluorescent DCP, and a method of making the same.

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Patent Owner(s)

Patent OwnerAddress
TEXAS TECH UNIVERSITY SYSTEMOFFICE OF RESEARCH COMMERCIALIZATION P O BOX 42007 LUBBOCK TX 79409-2007

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Punganuru, Surendra R Amarillo, US 1 0
Srivenugopal, Kalkunte S Amarillo, US 3 0

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