Transfection reagents for delivery of nucleic acids

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 11964057
APP PUB NO 20210154149A1
SERIAL NO

16621502

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Polymeric transfection reagents for delivery of nucleic acids to cells, pharmaceutical compositions comprising same, and methods of preparing and using same are provided. A compound comprises polyethylenimine, a lipid selected from cholesterol, lauric acid, palmitic acid, or stearic acid, and optionally, a histidine. A nanoparticle comprises the compound complexed to a nucleic acid. A composition or pharmaceutical composition comprises the nanoparticle and a pharmaceutically acceptable carrier, anti-fouling agent, targeting ligand, or combinations thereof. A method of treating, preventing, or ameliorating a disease in a subject comprises administering to the subject an effective amount of the nanoparticle or the composition or pharmaceutical composition.

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Patent Owner(s)

Patent OwnerAddress
RJH BIOSCIENCES INC10443 - 32 AVENUE EDMONTON T6J 4J1

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kc, Remant Badahur Edmonton, CA 2 0
Uludag, Hasan Edmonton, CA 6 8
Valencia-Serna, Juliana Edmonton, CA 1 0

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