Methods for high-resolution genome-wide functional dissection of transcriptional regulatory regions

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United States of America Patent

PATENT NO 11987790
APP PUB NO 20200407710A1
SERIAL NO

16757296

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Abstract

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Embodiments disclosed herein provide a general, scalable, high-throughput, and high-resolution approach for experimental dissection of regulatory regions and driver nucleotides in the context of human biology and disease. Applicants present HiDRA, a novel high-resolution global screen for transcriptional regulatory activity in accessible chromatin regions, enabling high-efficiency, high-throughput, and high-resolution inference of regulatory activity.

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MASSACHUSETTS INSTITUTE OF TECHNOLOGY77 MASSACHUSETTS AVENUE CAMBRIDGE MA 02139

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Claussnitzer, Melina Boston, US 5 0
He, Liang Cambridge, US 84 370
Kellis, Manolis Cambridge, US 9 98
Wang, Xinchen Cambridge, US 3 0

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