Single-cell genomic methods to generate ex vivo cell systems that recapitulate in vivo biology with improved fidelity

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United States of America Patent

PATENT NO 11994512
APP PUB NO 20190204299A1
SERIAL NO

16240361

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Abstract

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Disclosed here is a generally applicable framework that utilizes massively-parallel single-cell RNA-seq to compare cell types/states found in vivo to those of in vitro models. Furthermore, Applicants leverage identified discrepancies to improve model fidelity. Applicants uncover fundamental gene expression differences in lineage-defining genes between in vivo systems and in vitro systems. Using this information, molecular interventions are identified for rationally improving the physiological fidelity of the in vitro system. Applicants demonstrated functional (antimicrobial activity, niche support) improvements in Paneth cell physiology using the methods.

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Patent Owner(s)

Patent OwnerAddress
THE BRIGHAM AND WOMEN'S HOSPITAL INC75 FRANCIS STREET BOSTON MA 02115

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Karp, Jeffrey Boston, US 12 108
Langer, Robert Cambridge, US 306 7077
Mead, Benjamin E Cambridge, US 3 0
Ordovas-Montanes, Jose Cambridge, US 6 10
Shalek, Alexander K Cambridge, US 51 474

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