Synthesis of boronate ester derivatives and uses thereof

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United States of America Patent

PATENT NO 11999757
APP PUB NO 20200308197A1
SERIAL NO

16760369

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Abstract

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Disclosed herein are methods for the preparation of boronate derivatives in the synthesis of antimicrobial compounds and uses thereof. Disclosed herein includes method of making a compound of Formula (B) by reducing the ketone group of the keto-ester compound of Formula (A), and the reduction can be performed using a Ruthenium based catalyst system or using an alcohol dehydrogenase bioreduction system.

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Patent Owner(s)

Patent OwnerAddress
MELINTA THERAPEUTICS INC300 GEORGE STREET SUITE 301 NEW HAVEN CT 06511

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Boyer, Serge Henri San Diego, US 20 91
Hecker, Scott J Del Mar, US 57 306
Hermsen, Petrus J Horst, NL 3 0
Verzijl, Gerardus K M Well, NL 2 1

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