Variable heavy chain only libraries, methods of preparation thereof, and uses thereof

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United States of America

PATENT NO 12024796
SERIAL NO

17540612

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Abstract

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The present disclosure relates to designs and applications of Variable Heavy Only (VHO) domain regions. The present disclosure provides a VHO library of polynucleotides encoding VHO domains, wherein the VHO domains are designed based on the Vh domain of a human Vh family, and a method of generating the VHO library. The present disclosure also provides a phage library displaying the VHO domains encoded by the VHO library through the use of M13 bacteriophage minor coat proteins such as pIX and pVII and a method of generating the phage library. The present disclosure also provides a method of screening the phage library to identify VHO candidates that are capable of binding a target of interest.

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Patent Owner(s)

Patent OwnerAddress
TAVOTEK BIOTHERAPEUTICS (HONG KONG) LIMITEDUNIT D 11/F FOUR SEAS COMMUNICATION BANK BUILDING NO 49-51 BONHAM STRAND WEST SHUNG WAN

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chiu, Mark L Paoli, US 2 16
Fung, Man-Cheong Ringoes, US 6 2
Tornetta, Mark Anthony Collegeville, US 1 0
Whitaker, Brian Downington, US 10 69

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