Oligonucleotide encoded chemical libraries

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United States of America Patent

PATENT NO 12030057
APP PUB NO 20230234065A1
SERIAL NO

18151343

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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This application provides a bead with a covalently attached chemical compound and a covalently attached DNA barcode and methods for using such beads. The bead has many substantially identical copies of the chemical compound and many substantially identical copies of the DNA barcode. The compound consists of one or more chemical monomers, where the DNA barcode takes the form of barcode modules, where each module corresponds to and allows identification of a corresponding chemical monomer. The nucleic acid barcode can have a concatenated structure or an orthogonal structure. Provided are method for sequencing the bead-bound nucleic acid barcode, for cleaving the compound from the bead, and for assessing biological activity of the released compound.

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Patent Owner(s)

Patent OwnerAddress
PLEXIUM INC9330 SCRANTON ROAD SUITE 500 SAN DIEGO CA 92121

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
MacConnell, Andrew Boyd San Diego, US 9 77
Rokicki, Joseph Franklin San Diego, US 9 77
Vijayan, Kandaswamy San Diego, US 55 1127

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