Enzymatic synthesis of 4′-ethynyl nucleoside analogs

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United States of America Patent

PATENT NO 12037623
APP PUB NO 20220228184A1
SERIAL NO

17257792

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Abstract

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The present invention relates to an enzymatic synthesis of 4′-ethynyl-2′-deoxy nucleosides and analogs thereof, for example EFdA, that eliminates the use of protecting groups on the intermediates, improves the stereoselectivity of glycosylation and reduces the number of process steps needed to make said compounds. It also relates to the novel intermediates employed in the process.

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Patent Owner(s)

  • MERCK SHARP & DOHME LLC

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Campos, Kevin R Berkeley Heights, US 12 9
Devine, Paul N Tinton Falls, US 32 139
Fryszkowska, Anna New York, US 23 11
Huffman, Mark A Warren, US 20 84
Kolev, Joshua N Califon, US 7 2
Nawrat, Christopher C Garwood, US 2 0
Truppo, Matthew Princeton, US 6 4

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