Process for the purification of oligonucleotides

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United States of America Patent

PATENT NO 12043642
APP PUB NO 20210347800A1
SERIAL NO

17236501

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Abstract

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The invention relates to a new process for the purification of oligonucleotides which comprises the removal of the acid labile 5′hydroxy protecting group at the 5′-O-oligonucleotide terminus of the oligonucleotide by way of tangential flow filtration with an acidic buffer solution. The process requires less steps and allows a higher degree of automation.

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Patent Owner(s)

Patent OwnerAddress
HOFFMANN-LA ROCHE INC150 CLOVE ROAD OVERLOOK AT GREAT NOTCH SUITE 8 LITTLE FALLS NJ 07424

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Lill, Joerg Aarau, CH 5 1
Sladojevich, Filippo Rheinfelden, CH 6 0

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