Synthesis of phosphate derivatives

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United States of America Patent

PATENT NO 12054511
APP PUB NO 20220402962A1
SERIAL NO

17888312

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Abstract

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The present invention is a process for the preparation of certain 5′-phosphoramidate nucleotide diastereoisomers. The phosphoramidates include those useful in the treatment of cancer such as NUC-3373 (5-fluoro-2′-deoxyuridine-5′-O-[1-naphthyl(benzyloxy-L-alaninyl)]phosphate].

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NUCANA PLCEDINBURGH EH12 9DT

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dammalapati, Venkata Lakshmi Narasimha Rao Hyderabad, IN 14 34
Griffith, Hugh Central Scotland, GB 37 176
Kennovin, Gordon Central Scotland, GB 9 67
Kotala, Mani Bushan Hyderabad, IN 11 34

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