Cells for characterization of botulinum neurotoxins

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United States of America Patent

PATENT NO 12054516
APP PUB NO 20240002443A1
SERIAL NO

18137604

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Abstract

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Recombinant nucleic acids encoding reporting constructs for characterizing botulinum neurotoxin protease activity and cells that incorporate such recombinant nucleic acids and that are suitable for use in cell-based assays for the neurotoxin are provided. The encoded reporting constructs are a pair of recombinant hybrid proteins that act in concert. The reporting constructs are a pair of recombinant hybrid proteins that act in concert, and that include a botulinum neurotoxin protease recognition and cleavage sequence positioned to release a fluorophore upon cleavage.

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Patent Owner(s)

Patent OwnerAddress
BIOMADISON INC1568 LUNETA DRIVE DEL MAR CA 92014

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dunning, Francis Mark Madison, US 12 19
Tucker, Ward C Monona, US 29 120

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