Methods for purification of messenger RNA

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United States of America Patent

PATENT NO 12060381
APP PUB NO 20220402959A1
SERIAL NO

17811029

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Abstract

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The present invention provides, among other things, methods of purifying messenger RNA (mRNA) including the steps of (a) precipitating mRNA from an impure preparation; (b) subjecting the impure preparation comprising precipitated mRNA to a purification process involving membrane filtration such that the precipitated mRNA is captured by a membrane; and (c) eluting the captured precipitated mRNA from the membrane by re-solubilizing the mRNA, thereby resulting in a purified mRNA solution. In some embodiments, a purification process involving membrane filtration suitable for the present invention is tangential flow filtration.

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Patent Owner(s)

  • TRANSLATE BIO, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
DeRosa, Frank Cambridge, US 261 2650
Dias, Anusha Cambridge, US 61 360
Heartlein, Michael Cambridge, US 223 2893
Karve, Shrirang Cambridge, US 119 337

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