Recovering long-range linkage information from preserved samples

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United States of America Patent

PATENT NO 12065691
APP PUB NO 20210371904A1
SERIAL NO

17166394

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Abstract

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The disclosure provides methods to isolate genome or chromosome level structural information from preserved samples. In some cases, samples preserved under conditions where long-range nucleic acid information is believed to be irreparably lost, such as FFPE samples, are treated to recover nucleic acid-protein complexes stabilized as part of the sample preservation process. The complexes are processed so as to recover information regarding which nucleic acids are bound to a common complex, and the information is used to recover genomic structural information.

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Patent Owner(s)

Patent OwnerAddress
DOVETAIL GENOMICS LLC100 ENTERPRISE WAY SUITE A101 SCOTTS VALLEY CA 95066

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Blanchette, Marco Santa Cruz, US 8 11
Hartley, Paul San Jose, US 14 121
Powers, Martin P San Francisco, US 2 7
Putnam, Nicholas H Waltham, US 7 26
Troll, Christopher John Santa Cruz, US 5 12

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