High efficiency library-identified AAV vectors

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United States of America Patent

PATENT NO 12091659
APP PUB NO 20200354714A1
SERIAL NO

16879914

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Abstract

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Aspects of the disclosure relate to barcoded chimeric adeno-associated virus (AAV) capsid libraries, chimeric capsids and related recombinant AAVs (rAAVs) identified using the libraries. Specifically, the chimeric AAV capsid libraries comprise a plurality of nucleic adds encoding AAV capsid proteins, wherein each nucleic acid (i) encodes a unique AAV capsid protein having distinct polypeptide regions of greater than six amino acids in length that are derived from at least two different AAV serotypes, and (ii) comprises a unique barcode sequence. Further disclosed are methods of preparing an AAV library and identifying AAV capsids tropic for a target tissue.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITY OF MASSACHUSETTSONE BEACON STREET 31ST FLOOR BOSTON MA 02108

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Choudhury, Sourav Roy Worcester, US 13 59
Esteves, Miguel Sena Worcester, US 20 60

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