Conditionally active biological proteins

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United States of America

PATENT NO 12110611
SERIAL NO

17573389

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Abstract

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Methods of generating conditionally active biologic proteins, in particular therapeutic or diagnostic proteins, which are more active at an aberrant condition than at a normal physiological condition. The methods include discovery methods using libraries of proteins and assays employing physiological concentrations of components of bodily fluids. The conditionally active biologic proteins may be further evolved, conjugated to other molecules, masked, reduced in activity by attaching a cleavable moiety. Criteria for selecting starting proteins for the discovery methods, as well as formats of the proteins are also disclosed.

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Patent Owner(s)

Patent OwnerAddress
BIOATLA INCSAN DIEGO CA 92121

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chang, Hwai Wen San Marcos, US 89 1213
Frey, Gerhard San Diego, US 107 962
Short, Jay M Del Mar, US 274 5063

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